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KMID : 0043320080310070843
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Archives of Pharmacal Research
2008 Volume.31 No. 7 p.843 ~ p.849
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Synthesis of 3’-C-Hydroxymethyl-substituted Pyrimidine and Purine Nucleosides as Potential Anti-Hepatitis C Virus (HCV) Agents
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Pei Xiaojuan
Choi Won-Jun
Kim Yu-Min
Zhao Long Xuan
Jeong Lak-Shin
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Abstract
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On the basis of potent anti-hepatitis C virus (HCV) activity of 2’-C-hydroxymethyladenosine, 3’-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.
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KEYWORD
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3’-C-hydroxymethyl nucleosides, Anti-hepatitis C virus (HCV) activity, Neighboring group effect, Stereoselective Grignard reaction
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